Systemic Therapeutics at SDDS 2024
Members of Systemic Therapeutics attended the Stanford Drug Discovery Symposium 2024 from April 29 - 30.
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- Mar 21
Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort
This study demonstrates that the neuroprotection of coffee on PD is attributed to caffeine and its metabolites.
- Feb 9
Characterization of caffeine response regulatory variants in vascular endothelial cells
In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression
- Jan 8
Targeting proprotein convertase subtilisin/kexin type 9(PCSK9): from bench to bedside
This ground-breaking research suggested that PCSK9 could degrade CD36
- Sep 30, 2023
Roles of Coffee and Its Components in Liver Diseases
coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis
- Sep 7, 2023
Current therapeutic targets and multifaceted physiological impacts of caffeine
caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2
- Mar 10, 2023
Effect of PCSK9 on atherosclerotic cardiovascular diseases and its mechanisms: Focus on immune regulation
Caffeine inhibits the expression of SREBP2 at the transcriptional level by increasing the Ca2+ concentration in the hepatic ER
- Sep 17, 2022
Drinking tea may lower the risk of diabetes, heart disease and death, mounting research shows
Mounting evidence suggests that drinking several cups of tea per day has numerous health benefits.
- Jul 29, 2022
Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
To reduce ER stress, Lebeau et al. screened for compounds that enhance ER-entry of Ca2+
- Feb 18, 2022
Study: Caffeine Impacts Expression of Genes Known to Mediate Cardiovascular Risk
Evidence suggests that caffeine reduces cardiovascular disease risk.
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