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How Moderate Coffee Drinking Could Transform Your Health
A look at the protective effects of coffee, tea, and caffeine consumption on cardiometabolic health.
Jan 1


Caffeine is linked to Heart Disease Risk in Some: Does it in You?
Caffeine is linked to Heart Disease Risk in Some: Does it in You?
Jan 1


Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity
Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM.
Sep 17, 2024


Novel caffeine derivatives mitigate hyperlipidemia by reducing PCSK9 expression and secretion
We have developed novel caffeine derivatives that markedly reduce PCSK9 expression/secretion.
Sep 1, 2024


Systemic Therapeutics at SDDS 2024
Members of Systemic Therapeutics attended the Stanford Drug Discovery Symposium 2024 from April 29 - 30.
Jun 1, 2024


Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort
This study demonstrates that the neuroprotection of coffee on PD is attributed to caffeine and its metabolites.
Mar 21, 2024


Characterization of caffeine response regulatory variants in vascular endothelial cells
In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression
Feb 9, 2024


Targeting proprotein convertase subtilisin/kexin type 9(PCSK9): from bench to bedside
This ground-breaking research suggested that PCSK9 could degrade CD36
Jan 8, 2024


Roles of Coffee and Its Components in Liver Diseases
coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis
Sep 30, 2023


Current therapeutic targets and multifaceted physiological impacts of caffeine
caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2
Sep 7, 2023
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