Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain.

In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with the abstinence group (64%).

Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM.

We have developed novel caffeine derivatives that markedly reduce PCSK9 expression/secretion.

In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression

This ground-breaking research suggested that PCSK9 could degrade CD36

coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis

caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2

Caffeine inhibits the expression of SREBP2 at the transcriptional level by increasing the Ca2+ concentration in the hepatic ER

To reduce ER stress, Lebeau et al. screened for compounds that enhance ER-entry of Ca2+