Characterization of caffeine response regulatory variants in vascular endothelial cells
In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression
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Jan 8
Targeting proprotein convertase subtilisin/kexin type 9(PCSK9): from bench to bedside
This ground-breaking research suggested that PCSK9 could degrade CD36
Sep 29, 2023
Roles of Coffee and Its Components in Liver Diseases
coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis
Sep 6, 2023
Current therapeutic targets and multifaceted physiological impacts of caffeine
caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2
Mar 10, 2023
Effect of PCSK9 on atherosclerotic cardiovascular diseases and its mechanisms: Focus on immune regulation
Caffeine inhibits the expression of SREBP2 at the transcriptional level by increasing the Ca2+ concentration in the hepatic ER
Jul 28, 2022
Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
To reduce ER stress, Lebeau et al. screened for compounds that enhance ER-entry of Ca2+
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