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Study: Caffeine Impacts Expression of Genes Known to Mediate Cardiovascular Risk

Evidence suggests that caffeine reduces cardiovascular disease risk. However, the mechanism by which this occurs is still unknown. In a new study, researchers from McMaster University and elsewhere investigated the effect of caffeine on the expression of two regulators of circulating low-density lipoprotein (LDL) cholesterol — or ‘bad’ cholesterol — levels.


“Just two to three average-sized cups of coffee per day contains enough caffeine to trigger a cascade effect, which reduces the levels of LDL cholesterol,” said McMaster University’s Professor Richard Austin, senior author of the study.


“High bloodstream levels of LDL cholesterol are associated with an increased risk of cardiovascular disease.”


“Regular caffeine consumption is linked to reduced blood levels of the PCSK9 protein, which increases the liver’s ability to remove excess LDL cholesterol from the bloodstream.”

“Coffee and tea drinkers have another important health reason to rejoice — minus the sugar,” he added.


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