Members of Systemic Therapeutics attended the Stanford Drug Discovery Symposium 2024 from April 29 - 30.

This study demonstrates that the neuroprotection of coffee on PD is attributed to caffeine and its metabolites.

In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression

This ground-breaking research suggested that PCSK9 could degrade CD36

coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis

caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2

Caffeine inhibits the expression of SREBP2 at the transcriptional level by increasing the Ca2+ concentration in the hepatic ER

Systemic Therapeutics investigators have been approved for FedDev funding from the SOPHIE program.

Mounting evidence suggests that drinking several cups of tea per day has numerous health benefits.

To reduce ER stress, Lebeau et al. screened for compounds that enhance ER-entry of Ca2+